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You may attempt sexual activity at any time between doses.

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Fluoxetine; Olanzapine: Moderate Tadalafil is metabolized predominantly by the hepatic cytochrome P 3A4 isoenzyme and inhibitors of CYP3A4, such as fluoxetine, may Erectile Dysfunction causes tadalafil clearance. Fluvoxamine: Major Avoid coadministration of fluvoxamine and tadalafil for the treatment of pulmonary hypertension. Potent inhibitors of CYP3A4, such as fluvoxamine, may reduce tadalafil clearance.

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Subjects were excluded if they had any clinically relevant abnormalities as determined by medical history, physical examination, blood chemistry, complete blood count CBCurinalysis, and electrocardiogram ECGor impotence they had a positive urine drug screen or alcohol breath test. All subjects were required to use a medically acceptable method of contraception throughout the entire study period and for 3 months after study completion.

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